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If the above is not reason enough, here is a more scientific explanation: Drying bud converts crude acidic THC from its nonactive form into a neutral pH psychoactive substance. Each THC molecule has to lose it's moisture content in order to become fully psychoactive. As Fatima mentioned, heating can make THC readily active by immedietly vaporizing the bud's moisture content away.

However, as Fatima also mentioned, aging is important too. First the bud is "dried", but can still contain some moisture within. By using the "cure", the THC slowly becomes psychoactive.

Curing builds a more uniformily dried bud with a better burn and taste. Almost all the THC converts to the usable psychoactive cannabinoid over the alotted time, without the degradation from drying the bud rapidly with heat. According to Starkes and Clarke, cured buds undergo a: Reduction in Chlorophyll content, Reduction in plant starch content, Reduction in nitrate levels, Loss of moisture, Loss of volitile terpenoids, and the polycyclic aromatization of other terpenoids.

All of these phenomena reperesent a loss in weight, and gain in net potency except for the polycyclic aromatization of terpenoids which affects flavor.

Note: over time THC will start converting to useless cannabinol CBN , which it can do in its carboxylized form no problem. Cured buds pack in bowls easier and break down into blunts and joints without difficulty.

Hash that has been cured forms a beautiful rhine around the outside with a rich creamy inside. Cured bud and hash is great and worth the trouble. The taste is awesome as all the excess chlorophyll has been broken down. A smoother smoke is created. In my mind, curing bud is like tenderizing meats Post reply. Insert quotes…. Similar threads. But a slow dry definitely helps with the smoothness of the smoke and flavor.

The aim of what you are doing is evenly finishing the slow dry process, so that mold will not grow when the buds are stored long term. I don't know about all this. But possibly. When you see the trics go from milky to amber It is caused by oxidation. It changes from one cannibinoid to another, I think cannibinol.

Maybe curing does something similar. Where's an expert?? Well i'm definitely not an expert but i have read several places among them a blog for biologists discussing this. Can't remember all the fancy details, but i remember the essence: "Marijuana WILL increase potency if cured properly" I think i feel the difference.

The well stored jars that have been stored for months or so definitely never dissapoints me ;O. Wordz Well-Known Member. Most of my last harvest was dried for about a week and a half without any curing, and the high didn't seem "complete", it was more along the lines of a strong buzz that would last only about minutes at max. After the rest of the dried buds were cured in glass mason jars, the length of the high increased significantly.

From that experience I'm convinced curing is a necessary stage to bring out the full psychoactive properties of cannabis. There are no reports on its activity in humans, and it is found in small amounts, if at all, in fresh plant material. If "Potency" is defined as a feeling that takes you away from the normal everyday state of awareness unaffected by anything added to the body, then Yes, curing does increase potency. Curing further reduces the amount of moisture in weed after the initial drying and during that reduction, the ratio between the amount of plant matter and the substances that take you away from a non-high state increases to more of that latter.

The high may be more "couch-lock", but it is more high, less plant matter. If the point in getting high is to not be straight, then curing most definitely increases the potency of pot. BTW, I was curing pot when the guys writing the grow books were still pulling milk out of mama. They should have asked ME!

There are many different cannabinoids in cannabis that have their own unique effect and can have a strong influence on the high. While cannabinol may be of a higher concentration in cured buds, it's hard to say what the levels of other cannabinoids are for cured buds.

POTUS said:. From everything I have read, once you harvest your plant THC production stops, but the THC can degrade into other psychoactive cannabinoids. BUT these other psychoactive cannabinoids tend to give a more couch-lock type of high. I personally do NOT like the couch-lock zoned out high. I prefer an up-high which is why I grow sativas.

So should I be curing at all or will I get a better up-high if I don't cure? Also no scientific link has been found between pot and depression. Kupunakane Guest. Yo Ho Peeps, I got this idea going in my head now. Since we all agree that drying and curing improves the taste of the smoke, Then I think that we also have more than enough folks here to do our own study.

I too love the learning, and studying process, and what better place than here amongst all our friends. Joined Feb 16, Messages Reaction score There have been a zillion Psychological studies that have come to the conclusion that many people are prone to depression when they use pot.

A simple Google on "Psychology depression" will bring back a load. Studies involving people and pot are usually done on people with no history of pot use. That gives them a good base with no pre-drawn conclusions or experiences. KingKahuuna said:. You must log in or register to reply here. Latest posts. Do you grind your weed before smoking it?

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I personally believe it is bad net code causing the Lag spikes in game. You will get the lag spikes even running at low quality.

Im running a GTX and lags all the time. Firstly, it's a laptop. Secondly, the servers do have slight hic-ups. Thirdly, it's a laptop. I don't hate on laptops nore do I bash G1 for their occasional freeze-ups in either their actual servers or their netcode. Simply stated all of the above are not helpful in game play. I honestly don't care how new or old your hardware is, it's not up to the challenge of playing this game. This is easy to remedy. I could compile a proper APBCompat.

Sign up for free! What do you need help on? Cancel X. Topic Archived Page 1 2 3 4 5 of 5 Next Last. Sign Up for free or Log In if you already have an account to be able to post messages, change how messages are displayed, and view media in posts.

User Info: BrolyvsSnake. Batman with planning always wins. He is only rivaled by Jackie Chan with a room full of furniture. User Info: Celestial-Fox. That was my first reaction to it once it booted up was "wow, this is gonna be a fun launch party".

I'd give it about 2 months to clear up noticeably, but even with driving that could give a pirated copy of GTA 4 as run for its money, this game is pretty fun already. Rest well bigtre User Info: iphan4tic. It's several years old actually. Besides, when has being new ever been an excuse for performance this bad?

It's quite rare for a game to be released with a frame rate this poor. I've never experienced performance this bad on a console game, not even other mmos. Growl, growl! User Info: Darkwolf But my guess it's that the MsgHook. Same problem for Ultramon. Seems like you need to shut off every programm which Battleeye doesn't support. It show you always the dll. Resolved Bugs. Search In. Existing user? Sign In Sign in with GamersFirst. Forum rules. Sign in to follow this Followers 1.

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Scientists are closer to understanding the formation of underwater megaplumes, large and powerful columns of heated water rising from the ocean floor.

Ion-Pump Photovoltaics. Battery boost found by mimicking the wonders of bamboo. Polymers clean up mercury, oil spills, nitrogen runoff, and more. A Whale of a Solution to Climate Change.

A three-day ship journey off the Mexican coast brought Maya Tolstoy to a part of an ocean known only by its map coordinates. Below was the East Pacific Rise, a point in the ocean floor where continents move apart, causing magma contained in the Earth's core to rise to the surface and spew from underwater volcanoes.

Into these depths, Tolstoy, a marine geophysicist with the Lamont-Doherty Earth Observatory of Columbia University, dropped 12 seismographs. They would help her track volcanism at the seabed. Her quest was driven by an attempt to measure the contribution such underwater volcanoes make to the global climate over thousands of years. They spew lava, carbon dioxide and other elements into the deep oceans. The carbon gets trapped in circulating water, cycled to different regions of the ocean, where it gets caught up in upwelling currents and emitted to the atmosphere.

The process can take up to 2, years and adds a fraction of the 88 million metric tons of carbon belched out by the volcanoes to the atmosphere. Tolstoy wanted to figure out how often these volcanoes erupt and what causes their eruption. Her ocean voyage happened in , and five years later, her research was published this week in Geophysical Research Letters. In it, she finds that the Earth's volcanism is tied to minute shifts in motion of the Earth around the sun, as well as to sea levels, in a chain of events that scientists have never before envisioned.

This pillow lava, along with slower-cooling magma beneath it, forms the vast majority of oceanic crust. Frequent eruptions along divergent plate boundaries such as the Mid-Atlantic Ridge form new ocean bottom in a process known as seafloor spreading. August 31, August 17, Subscribe Sign up for our newsletter! Calendar Twitter Facebook.






















A person who experiences a change in their sense of smell should take note of any other new symptoms that they are experiencing. If the cause of hyperosmia is not clear, a doctor may then order more tests to work out the cause.

Possible tests may include blood tests and imaging tests. In many cases, the best treatment for hyperosmia is to avoid smells that cause it.

Trigger smells may vary from person to person but can include strong chemical smells and particular food. When it is not possible to avoid a smell, a person may find it helps to chew peppermint gum or suck peppermint candy until they can move away from the cause of the odor. A doctor may prescribe medications to treat the underlying conditions that cause hyperosmia.

For example, people who experience migraines might find that migraine medication helps relieve hyperosmia. People with hyperosmia due to disorders affecting the nervous system may also benefit from taking medications for their condition. Sometimes, surgery is required to remove growths in the skull or nose if they are causing the hyperosmia. When a doctor can identify the underlying condition, they can successfully help people with hyperosmia find relief from their heightened sense of smell.

Ticks are parasites that feed on blood. Their bites can sometimes transmit diseases. Learn how to spot a tick bite and what to do if one happens. With recent reports of a rise in Lyme disease cases, we try to find out just how worried should we be about the pesky bugs closely associated with the…. Addison's disease, also called chronic insufficiency of the adrenal cortex, affects the adrenal glands. Learn about the possible causes of this….

Lyme disease is commonly caused by ticks. Another lesser-known risk of tick bites is babesia, a dangerous microparasite that can infect human blood…. What is hyperosmia and what causes it? Medically reviewed by Seunggu Han, M. Share on Pinterest A person with hyperosmia has a heightened sense of smell.

Share on Pinterest A pregnant woman may experience hyperosma because of hormonal changes. HG demonstrated taste and smell impairment and increased NV responses to many tastes and smells. Crunchy sweet uncooked food apple or watermelon maybe best tolerated in HG.

More than two thirds of pregnant women experienced nausea and vomiting NVP during early pregnancy with the more severe presentation, hyperemesis gravidarum HG affecting about 1. In HG, nausea and vomiting is profound resulting in dehydration and starvation with hospitalization typically needed 2 , 3.

In HG, sensitivity to sweet taste and taste threshold levels were significantly lower with a considerable alteration in taste perception 4. A 3-arm study reported that women affected by HG perfomed worst in taste identification when compared to healthy pregnant women or to healthy non-pregnant women, who performed similarly 5. Two thirds of the pregnant women rated their smell sensitivity to be enhanced in pregnancy but these self-ratings were not supported by formal test scores 6.

Smell threshold has been found to be higher in first trimester pregnant women but their discrimination of smell intensity was not different 7. Women in first trimester of pregnancy compared to non-pregnant controls had similar smell identification ability 8 but this finding is contradicted by another study which has reported a reduction in smell identification ability in the first trimeter of pregnancy compared to women later in pregnancy and to non-pregnant healthy women 9.

A 3-arm study reported that HG women performed the worst in smell identification, followed by healthy pregnant women then healthy non-pregnant women who performed the best 5. However, the ability by smell to differentiate safe from potentially harmful compounds does not undergo adaptation during pregnancy In early pregnancy, smell-induced nausea is independent of subjectively perceived intensity and appears to be due to the cognitive processing of olfactory input Dietary advice to women affected by NVP such as avoiding spicy or fatty food and preferring bland, dry, high protein food is typically based on expert opinion In the 12 months before pregnancy, moderate intake of water and adherence to a healthy diet that includes vegetables and fish are associated with a lower risk of developing HG On the other hand, high daily intake of total fat primarily saturated fat prepregnancy increases the risk of HG It is suggested that a combination of team support, individualized care, supplements created by the dietitian on the basis of patient preferences, and an adapted documented approach for patients with eating aberrations are important aspects of effective management of HG We aim to experimentally evaluate taste and smell identification capablility and tolerance and to obtain questionnaire-based data on tolerated food textures, type and cooking method in HG cases compared to gestational-age matched controls to provide a basis for dietary guidance in HG.

Recruited was from December 9, to June 10, The study was conducted in accordance with the Declaration of Helsinki on human experimentation.

Over six months of recruitment, a total of participants 62 HG cases and 62 controls were enrolled into the study. Exclusion criteria were extreme HG symptoms inability to complete taste and smell tests , language incapacity to respond to questionnaire or pre-existing taste or olfactory disorder. Eligible women were approached, provided with the patient information sheet and verbally counseled with regard to study participation; written informed consents were obtained from all participants.

At recruitment, participants were asked verbally if they feel more nauseous or feel like vomiting NV when considering eating i food with texture: crunchy, chewy, soft, pasty and liquid, ii specific food items: chicken, white fish, plain white bread, cream crackers plain rice, rice porridge, green vegetables and iii fruits: papaya, water melon, pineapple, banana, apple, orange, and grapes, iv food cooked by: deep-fry, stir-fry, barbeque, steam and roast using a 5-grade Likert scale response - Supplementary Fig.

Participants rinsed their mouth with plain water, paused for taste effect to dissipate before proceeding to the next taste test.

A short pause for smell effect to dissipate was given before proceeding to the next smell test. Written informed consents were taken from all participants.

Over a six months recruitment period, a total of participants 62 HG cases and 62 controls were enrolled into the study with no woman approached declining or too unwell HG cases to participate. All participants completed the study protocol. Table 1 depicts the characteristic of study participants stratified according to HG subjects vs. PUQE score 16 , as expected, were markedly and statistically significantly higher in the HG arm 13 [12—15] vs.

HG women were slightly younger. The remaining characteristics were similar across study arms. Fruits generally fared well with 5 of the 7 listed occupying the top 5 best tolerated positions amongst the 14 selected food items. Controls consistently do not expressed the NV response to any questionnaire items. In every comparison made, HG cases performed statistically significantly worst in NV rates than controls Table 2. The NV response rate were significantly higher in the HG arm for bitter, sour and salty but not for sweet when compared to controls.

In smell identification tests Table 4 on the 16 smells selected for the study, HG cases performed significantly worse than controls for 10 smells namely coconut, sesame, menthol, chocolate, ginger, peppermint, lemon, garlic, banana and fish compared to controls. HG cases compared to controls were more likely to have significantly higher NV response in all 16 smells tested. Their Score of Correct Smell Identification.

In a 3-arm study comprising HG affected women, healthy pregnant women and healthy non-pregnant women, with 4 base tastes assessed using taste sprays, taste identification scores were respectively 3. On the other hand, universally in controls no taste test provoked any NV response. Women with NVP are characterized by high intakes of carbohydrates and added sugar 17 and according to a multiethnic South African study pregnant women have pronounced craving for sweet foods 18 , our data that HG women find sweet taste least likely to provoke NV is consistent with a consumption pattern that favored added sugar in NVP women and craving for sweet foods in pregnancy.

The cause or effect of taste and smell deficits to HG cannot be established by this cross-sectional study; we do not have the longitudinal data to evaluate if these deficits predate or dissipate with recovery from HG.

Controls did not have a NV response to any of the five foods texture evaluated. Aversions to staple foods is reportedly common in pregnancy 21 and our finding is consistent with an exaggerated response in HG. None of the 14 food items evaluated evoked NV sensation in controls.

With all five cooking methods, a majority in HG arm expressed a NV response suggesting that the thought of eating cooked food was problematic.

None of the five cooking methods evoked NV sensation in controls. There was a confluence of findings that fruity lemon, banana and coconut smells were better tolerated and fruits like apples, watermelon, oranges and bananas least likely to provoke NV sensations when their eating was contemplated.

Food texture, cooking method and food item in terms of tolerance or preference were likely influenced by culinary heritage. However, preference for and tolerance to fresh fruits are quite likely to cut across the ethno-cultural and culinary boundaries.

The fruits selected for our questionnaire are widely consumed. We believe our finding that generally favored fresh fruits in HG could be generalizable. In pregnant women in Tanzania, fruits like mangos and oranges are craved and rice and fish avoided usually for no particular reason Our data for HG women finds oranges to be well tolerated and rice and fish amongst the worst tolerated reflecting a degree of symmetry with the Tanzanian data.

Increasing severity of nausea was also associated with decreasing prudent diet score from before to early pregnancy, such that women with severe nausea had prudent diet scores 0. This original study provided cross sectional data on the association of taste and smell defects in HG compared to controls. The selection of smells for our test panel of 16 is eclectic but commonly encountered in our population. This smells panel may restrict generalizability to other HG populations. Select personalised content.

Create a personalised content profile. Measure ad performance. Select basic ads. Create a personalised ads profile. Select personalised ads. Apply market research to generate audience insights. Measure content performance. Develop and improve products. List of Partners vendors. Hyperosmia is an increased sensitivity to smell, and it is often accompanied by unpleasant symptoms. It may occur intermittently, particularly when it happens in association with certain medical conditions, such as migraine or upper respiratory infections.

Less often, hyperosmia can also be genetic, usually manifesting as persistently heightened smell sensitivity. But if the symptoms are becoming bothersome for you, there are some treatments and coping strategies you can adopt to alleviate the negative effects. Interestingly, with hyperosmia, your sense of smell may be intensified for some odors but less sensitive to others. You can have a disagreeable reaction, a neutral response, or you may even enjoy your amplified sense of smell.

With hyperosmia, you are likely to have all three of the following types of reactions at one point. Hyperosmia may make certain smells particularly distasteful. You can feel nauseated or disgusted, and the odors can even trigger migraines or allergies.

There is a strong relationship between hyperosmia and osmophobia aversion to certain smells. Either of these conditions can lead to the other.

Despite the name, osmophobia is not necessarily a fear of bad smells. Instead, it is usually an extreme aversion and disgust. In some cases, osmophobia can progress to produce a fear of certain offending smells if you become anxious about the effects that certain odors may have on you.

The increased odor sensitivity of hyperosmia is not always negative. Hyperosmia allows you to detect and distinguish smells that do not necessarily provoke a disagreeable reaction, particularly if your hyperosmia is due to a genetic predisposition rather than a medical condition. If you have had hyperosmia since you were born, you might not even realize that you have the condition because your acute sense of smell feels normal for you.

Or you may be able to identify the difference between various smells with greater accuracy than most people you know. Some practical advantages of hyperosmia include detecting the location of a dangerous smell, like smoke or a chemical leak, or noticing that food is rotting.

On the other hand, it has been noted that heightened smell sensitivity can be associated with obesity. This is likely because your appetite and enjoyment of food rely not only on taste, but on smell as well. If you have noticed that food tends to smell more appetizing to you than to other people, you should discuss this with your healthcare provider if you are also overweight because it could affect your long-term health.

Some people naturally have a heightened sensitivity to smell all the time. This is believed to be genetic, and it has been linked with the SCN9A gene, which codes for sodium channels a component of nerve cells in the body.

This may not be the only gene associated with hyperosmia, however, and the condition could be related to several genes. You may also have episodes of hyperosmia at certain times, such as during pregnancy or when your allergies are acting up.

Some medical conditions can make you develop lasting hyperosmia, either suddenly or gradually. Several conditions are often characterized by hyperosmia and osmophobia. These conditions are typically episodic, like epilepsy, migraine, and allergies. Other conditions, such as toxin exposure, are not common and may be difficult to pinpoint.

Pregnancy : An increased sensitivity to smells is commonly reported in the first and second trimester of pregnancy. Hyperosmia can trigger nausea and vomiting, and it has been associated with hyperemesis gravidarum excessive vomiting during pregnancy typically requiring medical treatment and intravenous or IV fluids. Migraines : Heightened sensitivity as well as repulsion by certain odors is very common in the pre-migraine premonitory stage, as well as during the peak of a migraine.

This tends to diminish after a migraine subsides, but people with recurrent migraines tend to have increased sensitivity to smells even during migraine-free times. Allergies : Nasal congestion often occurs with allergies that affect the upper respiratory system. This can interfere with the detection of smell. Ironically, allergies are also associated with hyperosmia during as well as in between allergy attacks.

This is thought to be related to alterations in superficial nerve sensors in nasal passageways. Upper respiratory infection : A sinus infection can give you a stuffy nose.

While your smell detection can be obscured, you can develop hyperosmia to some smells, too. Epilepsy : An exaggerated sense of smell can occur as a pre-seizure aura. In rare instances, hyperosmia can also be present during or after a seizure. If the odor is not present at all, you may not necessarily be experiencing true hyperosmia, but your symptoms may be described this way. Toxin exposure : There are numerous reports of hyperosmia beginning after exposure to toxins such as lead or mercury.

Sometimes, this effect becomes obvious after several people who were exposed to the same chemical are diagnosed with similar effects. You could be exposed to neurotoxic chemicals in an industrial setting or through the use of medications or cosmetics.

An alteration in smell sensation is not the predominant or most common symptom of any of these conditions, but hyperosmia has been reported frequently enough that it is among the well-recognized effects. While hyposmia is usually the cause of decreased appetite and weight loss, hyperosmia often accompanies the hyposmia. This is because there is an alteration of the whole olfactory smelling system, not just a decrease in function. Furthermore, it is usually the unpleasant smells that are most noticeable, although this could be simply because people are more likely to notice and react to unpleasant smells than to pleasant smells.

Odor detection and identification are controlled by the olfactory nerve , also described as cranial nerve one or the first cranial nerve.






















Benefits of RNA Sequencing. Download eBook. Access PDF. New To NGS? Find out how Illumina NGS technology works and what types of experiments it enables. Microarrays RNA-Seq vs. Learn More Ribosome Profiling Deeply sequence ribosome-protected mRNA fragments to gain a complete view of the ribosomes active in a cell at a specific time point, and predict protein abundance. Learn More. Frequently Purchased Together. Your items have been added to the cart.

Continue Shopping Go to Cart. Read Customer Interview. The Time Is Now for Microbiome Studies Transcriptomics and whole-genome shotgun sequencing provide researchers and pharmaceutical companies with data to refine drug discovery and development. Read Interview. Read Technical Bulletin. Featured Products. Illumina Stranded mRNA Prep A simple, scalable, cost-effective, rapid single-day solution for analyzing the coding transcriptome leveraging as little as 25 ng input of standard non-degraded RNA.

View Product. Interested in receiving newsletters, case studies, and information on genomic analysis techniques? Enter your email address. Additional Resources. Download Now. Revisiting global gene expression analysis. Qing, T. China Life Sci. Leshkowitz, D. Using synthetic mouse spike-in transcripts to evaluate RNA-seq analysis tools.

Lun, A. Assessing the reliability of spike-in normalization for analyses of single-cell RNA sequencing data. Ritchie, M. Limma powers differential expression analyses for RNA-sequencing and microarray studies.

Love, M. Law, C. Voom: precision weights unlock linear model analysis tools for RNA-seq read counts. Frazee, A. Ballgown bridges the gap between transcriptome assembly and expression analysis. Rapaport, F. Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data.

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Svensson, V. Exponential scaling of single-cell RNA-seq in the past decade. This review is an excellent introduction to the full range of single-cell sequencing methods. Leelatian, N. Single cell analysis of human tissues and solid tumors with mass cytometry.

Cytometry B 92 , 68—78 A useful description of the pitfalls of tissue dissociation for users of single-cell sequencing to consider. Hines, W. Sorting out the FACS: a devil in the details.

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In vivo probing of nascent RNA structures reveals principles of cotranscriptional folding. Novoa, E. Best practices for genome-wide RNA structure analysis: combination of mutational profiles and drop-off information.

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Kudla, G. Kretz, M. Engreitz, J. Lu, Z. RNA duplex map in living cells reveals higher-order transcriptome structure. Aw, J. In vivo mapping of eukaryotic RNA interactomes reveals principles of higher-order organization and regulation. RNA sequencing RNA-seq allows researchers to uncover these issues and obtain snapshots of a cell, tissue or organism at specific moments in time.

This series will discuss RNA-seq from start to finish though not in comprehensive detail , including how to set up a good RNA-seq experiment and how to deal with the resulting data. For now, though, we will simply discuss why RNA-seq may be the right choice for your next gene expression experiment.

Where DNA is the underlying blueprint for all cellular processes, RNA is the molecule produced on demand when those processes are needed. Proteins translated from messenger RNA then carry out the encoded functions. It can reveal problems in the underlying DNA code, as well as defects in processing machinery that ultimately lead to disregulated gene expression or defective proteins.

For example, where a DNA coding region might look normal, a downstream transcriptional problem could lead to alternative splicing of the resulting RNA molecule, leading in turn to a non-functional enzyme and inducing a disease state. These splice variants might not be pathogenic, either.

In some cases, sequencing the RNA can reveal sequences that produce different protein isoforms. In cancer, kidney disease, cardiovascular conditions, autoimmune disease, and many more, changes in gene expression are the underlying cause.

Historically, researchers have used protein levels as a readout in these instances. RNA-seq holds a number of advantages over protein microarrays and their sister assay, RNA microarray.

First, RNA-seq has a much lower detection threshold than arrays learn more about the differences between the two assays in this blog post. The latter involve hybridization of isolated protein to an assay plate that includes a fluorescent marker. More protein causes a brighter signal. That signal has to be high enough for detection, though, necessitating a certain level of starting material. RNA-seq experiments require as little as picograms of starting material, and there are assays for RNA-seq on single cells.

See the Cofactor website for current offerings and sample submission requirements.






















In this way, moisturizing prevents pores from becoming clogged with oil, reducing their appearance. Using a clay mask once or twice a week can help remove additional oil from the pores.

This is because clay absorbs sebum. It is advisable to do this on a different day than exfoliating, as overtreating the skin may cause irritation. Irritation can cause pores to appear enlarged and can lead to blemishes. Sleeping in makeup overnight can cause the pores to become blocked due to a buildup of makeup, oil, and bacteria. It is crucial to care for the skin when in the sun. Sun exposure can dry the skin, making pores appear larger. Many moisturizers contain sunscreen.

People should choose one with an SPF of 30 or over. Each hair follicle has a pore at the top of it. The hair follicle has a gland inside it that produces oil. This gland is called the sebaceous gland. When the sebaceous gland releases oil, the oil rises to the top of the skin and collects in the pore.

According to a study , the main causes of enlarged pores are:. When oil collects in the pore and combines with dirt or makeup, the pore can become blocked. This blockage stretches the pore, making it look bigger.

If the pore remains clogged, a pimple may develop. Having large pores is not a health concern. As one study noted, pore size is purely an aesthetic consideration. An example of clay is kaolin, a natural clay that is added in skin formulations to help draw out excess sebum oil from the skin while gently exfoliating. This results in smaller looking pores.

Clay masks can be combined with other ingredients to best fit your skin concerns. For example, sulfur a natural antibacterial can fight acne, charcoal powder draws up oil, Vitamin E micro beads to replenish skin moisture, and pumpkin enzymes to help regenerate skin and refine pore size. To avoid skin irritation, masks should not be used more than twice a week. We offer different masks and scrubs to fit your skin type - acne, combo, dry, normal, oily and sensitive.

Exfoliation is the removal of dead skin cells from the upper skin layer. Exfoliation brightens skin as well as leaves you with a smoother texture. Alpha Hydroxy Acids are mostly derived from natural ingredients, glycolic acid from sugar cane, lactic acid from milk, malic acid from apples, citric acid from citrus and tartaric acid from grapes.

Beta Hydroxy Acids usually refer to salicylic acid. They are also oil soluble, meaning they are ideal for oily skin. They are also a great ingredient for calming red skin, even those who have rosacea.

You do not want to over exfoliate your skin though. If this occurs, decrease the frequency, strength or type of exfoliation. Choose the exfoliator that fits your skin type - acne, combo, dry, oily, normal, oily, sensitive. Moisturizing your skin everyday can reduce the chance of developing dry or oily skin — both which can cause acne.

The best moisturizers for enlarged pores should complement your skin type. Choose the moisturizer that best fits your skin type. Try experimenting with several kinds to see which work best for you. Good ones to try include clay or oatmeal masks.

Facial masks help draw out impurities from pores, making them look smaller. Take a look at the products available on Amazon.

Exfoliating your skin helps remove the things that clog up pores, such as oil and debris. Exfoliators work best when used daily or almost-daily. You can choose from a wide range of exfoliating products, including astringents, creams, and lotions. Some to try include:. See more products at Amazon. They work by rejuvenating collagen production and may be most effective for large pores caused by aging or sun damage.

They may also be effective at reducing acne scars. Steps include:. Open pores on your cheeks, nose, and forehead can appear larger as you age, or when your pores are clogged.

Keeping skin clean, and avoiding the sun, are two of the best ways you can reduce the appearance of open pores. While nothing actually opens or closes pores, treatments are available that can make them look smaller, giving you the appearance of healthier and more vibrant skin.

Pores play an incredibly important role in keeping our bodies healthy. They kind of work like a tunnel, allowing the body to deliver sebum from the sebaceous glands to the surface of the skin, where it works to moisturize and protect our largest organ — the skin itself.

Most people with large pores are simply born that way, likely having inherited their specific skin type. As we age and our skin loses its elasticity, it will often stretch or sag. This can cause pores to expand over time, making them more visible as we age. In addition to these factors, there are certain bad habits that can impact the size of them. Sun damage and over-washing are at the top of that list.

Both have a drying effect on the skin, and can either zap collagen which keeps skin plump and healthy looking or trigger more oil production. Boom clogged pores. While some people are born with smaller pores than others, there are certain bad habits that can impact the size of them. Sun damage and over-washing are at the top of the list.

Both have a drying effect on the skin, and this can either zap collagen which keeps skin plump and healthy looking or trigger more oil production. No matter how much time or money you spend on them, the size of your pores will never be made smaller with a product, treatment, or home remedy.

The good news?






















The elaborate ways we turn away from and avoid difficult emotions can get us into trouble that can wind up worse than the emotions from which we were running. There are several different types of avoidance. According to McKay and colleagues, situational avoidance is the most commonly used kind of avoidance.

People who use situational avoidance may fear certain individuals or kinds of people, locations that make them feel panicked or anxious, different kinds of animals, foods, activities, or social situations. Cognitive avoidance is about avoiding internal events such as unpleasant or distressing thoughts or memories. With this type of avoidance, people usually take actions to suppress or reject the experience of certain kinds of thoughts that feel unpleasant or overwhelming.

Strategies to avoid unwanted internal events may involve consciously telling oneself not to think about something, or taking action to numb out to the unwelcome thoughts.

Cognitive avoidance can also show up as worry and rumination. You might handle your anxiety about the future and various risks in your life by constantly worrying about what might happen, running various scenarios over and over in your mind in the hope that constant vigilance will somehow prevent anything bad from happening, write McKay, Fanning, and Ona.

Sometimes cognitive avoidance looks like trying to replace undesirable thoughts with other stufflike daydreams, repetitive phrases, even prayers. Positive affirmations are often helpful for people, but saying them compulsively can be a way to avoid distressing thoughts or memories rather than work with them in a way that may provide long-lasting relief.

McKay and colleagues discuss protective avoidance as the use of excessive safety behaviors that might include checking, cleaning, over preparing, or perfectionism.

Clients who present with symptoms of obsessive compulsive disorder and eating disorders often utilize protective avoidance strategies.

But there is a curious flip side of protective avoidance as well. Procrastination is also considered a form of protective avoidance. Anyone who has ever experienced anxiety knows that it is typically a combination of mental and physical symptoms.

Tightness in the chest, shallow breathing, increased heart rate and sweaty palms may all show up along with distressing thoughts when a person feels anxious. These behaviors are problematic because in the long run they only serve to increase fear. Avoidance behaviors can take three different forms: avoidance, escape or partial avoidance. True avoidance behaviors involve the complete avoidance of the feared social situation. For example, someone afraid of public speaking might:.

When total avoidance is impossible, escape behaviors may be used as a means of dealing with feared situations. Escape involves leaving or escaping from a feared social or performance situation. Some examples of escape include. When neither avoidance nor escape is possible, partial avoidance also known as safety behaviors may be used to alleviate feelings of anxiety during social or performance situations.

Safety behaviors generally limit or control your experience of a situation. If safety behaviors have become a way of life for you, it might be hard to even be able to recognize if you are using them.

They may have become habitual ways of behaving that now you don't even know what it would be like not to use them. If you continue to feel anxious in situations even after facing them many times, this is a clue that you might be using safety behaviors.

Notice situations that you face often but that still cause you anxiety—and then identify what you might be doing in those situations to avoid feeling anxious, such as talking fast, avoiding eye contact, or wearing plain clothes to avoid drawing attention to yourself. While not using safety behaviors will result in increased anxiety in the short term, over the long term, it will help you to overcome your anxiety. The problem with avoidance behaviors is that they maintain the symptoms of anxiety.

The safety behaviors are often assigned value for "surviving" social anxiety, but then blame for the anxiety or awkwardness is still placed upon the self, perpetuating the cycle. If you always avoid giving speeches, or if you only give speeches without making eye contact, your anxiety about giving a speech will never diminish.

These behaviors prevent you from gathering evidence that disproves your maladaptive beliefs about social situations.

For example, if you always leave a party at the first sign of anxiety, you never have the chance to learn that if you stay long enough in the situation, your anxiety will eventually diminish. Instead of avoiding giving speeches, or only delivering them in a "safe" way, you need exposure to giving speeches without avoiding, escaping or using safety behaviors.

In fact, research has demonstrated that exposure treatment one component of CBT for social anxiety disorder will be less effective when a person is using safety behaviors. This suggests that reducing your use of safety behaviors when entering therapy may help to give you a better result.

Are you looking for a quick way to reduce your avoidance? Draw on the principles of the therapies mentioned above. For example, you might do the following:.

If you have an urge to hide in the bathroom at the next party you attend, promise yourself to go back out for at least five minute intervals before you return. Gradually work your way up to longer periods of returning to the party. The first step to effective treatment is to have a diagnosis made, usually by a mental health specialist. Speak with your doctor or health care provider about the best treatment for you.

A type of psychotherapy called cognitive behavioral therapy CBT is especially useful for treating social anxiety disorder. CBT teaches you different ways of thinking, behaving, and reacting to situations that help you feel less anxious and fearful.

It can also help you learn and practice social skills. CBT delivered in a group format can be especially helpful.

For more information on psychotherapy, please visit www. Many people with social anxiety also find support groups helpful. In a group of people who all have social anxiety disorder, you can receive unbiased, honest feedback about how others in the group see you.

This way, you can learn that your thoughts about judgment and rejection are not true or are distorted. You can also learn how others with social anxiety disorder approach and overcome the fear of social situations. Anti-anxiety medications are powerful and begin working right away to reduce anxious feelings; however, these medications are usually not taken for long periods of time.

People can build up a tolerance if they are taken over a long period of time and may need higher and higher doses to get the same effect. Some people may even become dependent on them. To avoid these problems, doctors usually prescribe anti-anxiety medications for short periods, a practice that is especially helpful for older adults. Antidepressants are mainly used to treat depression, but are also helpful for the symptoms of social anxiety disorder.

In contrast to anti-anxiety medications, they may take several weeks to start working. Antidepressants may also cause side effects, such as headaches, nausea, or difficulty sleeping. These side effects are usually not severe for most people, especially if the dose starts off low and is increased slowly over time.

Talk to your doctor about any side effects that you have. Beta-blockers are medicines that can help block some of the physical symptoms of anxiety on the body, such as an increased heart rate, sweating, or tremors. Your doctor will work with you to find the best medication, dose, and duration of treatment.

Many people with social anxiety disorder obtain the best results with a combination of medication and CBT or other psychotherapies. Don't give up on treatment too quickly. Both psychotherapy and medication can take some time to work. A healthy lifestyle can also help combat anxiety.

Make sure to get enough sleep and exercise, eat a healthy diet, and turn to family and friends who you trust for support.

For basic information about these and other mental health medications, visit www. For information on clinical trials, visit: ClinicalTrials. For more information on conditions that affect mental health, resources, and research, visit the NIMH website www.

The Mental Health Treatment Locator section of the Behavioral Health Treatment Services Locator lists facilities providing mental health services to persons with mental illness. Find a facility in your state at findtreatment. For additional resources, visit www.






















I would prefer that no one saw. Shawn Johnson is calling for an even more extreme approach. Don't tell anybody. Video: Elfi Schlegel: Gymnasts have great shot at more medals.

Video: Gabby Douglas: 'I knew we could do it'. Pin collector chases Olympic metal. Obama calls gymnasts, tweets Phelps: 'You make our country proud'. IE 11 is not supported. For an optimal experience visit our site on another browser. So, too, a manicure deemed distracting enough to call the judges attention away from a perfect double layout and toward nail beds could be a costly beauty risk. These are not only women who can execute movements with their bodies that seemingly defy universal gravity laws, but they maintain a cool under pressure that most of us will never have to face.

Topics Olympic Games. Vogue Beauty The biggest beauty stories, trends, and product recommendations. When the U. Viewers quickly noticed, taking to to Twitter to discuss it. Well-adorned: Catherine Zeta-Jones tees off wearing a butterfly on her black scrunchie left , while Hillary Clinton sports a pearl scrunchie at the Chamber of Commerce right.

Most notable: the scrunchie is alive and well. Another user tweeted: 'Gymnastics: single-handedly keeping scrunchie manufacturers in business. Whatever the reason, from Olympic stage to retail stores, the scrunchie is turning up everywhere from American Apparel to Asos and even Marc by Marc Jacobs. The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline.

Argos AO. Privacy Policy Feedback. The return of the scrunchie: Is the much-maligned hair accessory making a comeback thanks to Olympic gymnasts? Share this article Share. Share or comment on this article: The return of the scrunchie: Is the much-maligned hair accessory making a comeback thanks to Olympic gymnasts?

Comments 65 Share what you think. View all. Bing Site Web Enter search term: Search. Mother of the bride Kathy is joined by husband Rick and son Conrad as they celebrate Paris's nuptials at family estate Kyle Richards wows in a flowing green dress as she arrives at niece Paris Hilton's star-studded wedding with husband Mauricio Umansky Plant power!

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List of Partners vendors. Are you a magnet for mosquitoes? Understanding what lures the insidious insects can be useful in avoiding them. Zika, West Nile, Malaria, Dengue Do you make mosquitoes swoon? Studies show that around 20 percent of people are especially irresistible. Some of these we can't do much about, but anything to help avoid the pests and reduce the use of dicey chemicals is worth the effort. As mentioned above, mosquitoes actually use their eyes to target victims.

Adult mosquitoes survive on nectar for nourishment, but females rely on the protein in our blood for the production of eggs. Research has found, in fact, that people with Type O blood are found to be almost twice as attractive to mosquitoes than those with Type A blood; Type B people were in the middle.

Mosquitoes can sense carbon dioxide from a significant distance, and they can see human from a distance of meters. Key to designing these is understanding what attracts and repels mosquitoes to certain individuals.

This opens the door to new tools or strategies for malaria vector control and surveillance such as chemical lures and traps. Our research group at the University of Pretoria is working on a project that seeks to answer the question: why do mosquitoes prefer certain individuals above others?

We were able to detect chemical differences between the two groups. Our findings open two possible lines of inquiry. Firstly, chemical compounds closely associated with mosquito attractive individuals could potentially be used in chemical lures to trap mosquitoes outdoors. And secondly, compounds closely related to individuals being unattractive to mosquitoes could be developed into new repellents.

Female mosquitoes need a blood meal for their eggs to develop. First, the female mosquito must find its host.

It can be quite selective. For example the Culex quinquefasciatus mosquito feeds exclusively on birds. Mosquitoes find themselves in complex environments filled with many different cues or stimuli. For them, the body temperature is higher. Those who have genetic prebondance to the same.

If you qualify for any of these mosquito-attracting attributes, stay safe. Always seek the guidance of your doctor or other qualified health professional for any questions you may have regarding your health or a medical condition.

The Indian Express website has been rated GREEN for its credibility and trustworthiness by Newsguard, a global service that rates news sources for their journalistic standards. Maybe the most important: Your metabolic rate, or the amount of carbon dioxide CO2 your body releases as it burns energy.

Mosquitoes use CO2 as their primary means of identifying bite targets, Day says. Also, drinking alcohol or physically exerting yourself raises your metabolic rate—and also your appeal to winged biters, he adds. While CO2 detection is the primary technique mosquitoes and other blood-sucking bugs use to spot hosts, they also rely on secondary cues to differentiate you from cars, decaying trees, and other CO2-producing objects.

And you can control some of those secondary cues, Day says. For example: Dark clothing is more attractive to mosquitoes than light oufits.






















This type of fiber provides retains water several times its weight, which helps to provide bulk to stool. Additionally, a Journal of Pharmacognosy and Phytochemistry review notes that the insoluble fiber in chia seeds speeds up gastrointestinal transit time as it helps to promote bowel movements. However, water must be consumed in adequate amounts for this to happen.

Otherwise, you could experience bloating as the body works to pass the fiber through your digestive tract. Although some people may experience bloating when consuming chia seeds, once your body adapts to eating higher, adequate levels of fiber, you'll be able to reap all the incredible benefits of chia seeds. The fiber in chia seeds has been found to help you stay full for longer, can help get rid of belly fat, may regulate blood sugar levels, and can help to reduce LDL harmful cholesterol from being absorbed into your bloodstream.

One way to reap the benefits of chia seeds without having to deal with any gastrointestinal distress is to soak the chia seeds in water before eating them. This might usually be a good thing, but if you're on medication to control your blood sugar , Zellner advises talking with your doctor before adding these seeds to your next smoothie.

But if you're not used to consuming foods that are super rich in fiber, Zellner says to remember that being pregnant can come with some digestive system changes — so pregnancy may not be the best time to start experimenting with chia-powered smoothies. If you're concerned about any of these side effects, Zellner advises chatting with your doctor and starting small.

Erica Zellner , certified nutrition specialist, health coach at Parsley Health. This article was originally published on June 9, But chia seeds — "which come from a species of flowering plant in the mint family native to central and southern Mexico and Guatemala" — are already so pervasive in the foodosphere, it may be hard to get that "proceed with caution" message across.

Nina Manolson , one of my go-to health coaches here in the Boston area told me she loves, loves, loves chia seeds. Here's her response to the quasi-ominous medical report:. Chia seeds live up to their superfood name. They are high in Omega 3's healthy fat that is an anti-inflammatory , they are an antioxidant, contain important micro-nutrients like magnesium, calcium and manganese and they are also loaded with protein. But possibly Chia's biggest claim to fame is its fiber content.

In 1 oz of chia seeds there are 11 grams of fibre - including both soluble and insoluble fiber. Insoluble fiber is the kind of fiber that acts like a scrub brush in your colon. Soluble fibre absorbs water so it creates bulk and it makes us feel full. The interesting thing about Chia seeds is that it can absorb A LOT of water - claims vary from X their weight in water, which makes it a great food to add to your diet if you're looking to feel satisfied for a long time without needing to eat a lot - as in trying to lose weight.

Chia seeds are also great at keeping dehydration at bay because it holds so much liquid. But if we don't have enough fluid to push it along, it's sitting in our stomachs and then we get constipated," Lockwood explains. You'll also want to avoid adding chia seeds to anything that's already rich in fiber, like salad that other surprising bloat culprit —it's just too much for the body to process all at once, she says.

If your diet is a little lacking in the fiber department, Lockwood says to start small when it comes to chia seeds, eating only one teaspoon at a time after soaking —AKA about one-third of the recommended serving size. And if that one teaspoon is causing you any discomfort, it's probably time to take a break from them all together—at least for now.

A little—but hey, there are other ways to get your superfoods and fiber. Chia seeds are still tiny wonders that have earned their protein-packed, omegaboosting rep. They're just a bit more powerful than you might have thought—kind of like those small but mighty moves you do at barre. Oh hi! Enter Email Address.






















Stockholm Business Region works closely with the business community, academic, and other institutions, as well as with various organizations in the city, other municipalities, and federal agencies. A selection of reports on business in Stockholm and also annual and monthly statistical reports on the tourism industry in the Stockholm region. Let us help you with your Stockholm story. If you are not or have not previously been registered in the Swedish population register, you can instead obtain a coordination number from the Swedish Tax Agency Skatteverket.

The coordination number is a temporary personal identity number that you will need, for example, when you apply for F-tax registration.

Personal identity numbers and coordination numbers at the Swedish Tax Agency. You cannot personally order a coordination number. The government agency you are dealing with will order a coordination number from the Swedish Tax Agency.

Before you start a business, you must first decide on the business type. The most common business type is to start as a sole trader.

That means that you, as a private individual, own, operate and are responsible for the business. Different business types. If you intend to operate as a sole trader, you are not required to register your company with the Swedish Companies Registration Office Bolagsverket. However, registration does protect the company name. If you do not register, someone else might register a company with the same name.

If you are going to start a limited company, a trading partnership, limited partnership or economic association, you must register your company with the Swedish Companies Registration Office. Business registration and tax. Business Sweden has a range of online tools and guides that will make your entry as smooth as possible. We also offer a free advisory service, available in English and Swedish. You are welcome to contact us if you have general questions about our services, markets and areas of expertise.

About Business Sweden Sweden is a powerhouse of innovation, sustainability, co-creation and equality. This makes it a formidable platform for companies to both expand upon and use as a brand that meets the demands in an increasingly purpose-driven world.

With a unique governmental and private sector mandate, we are specialists in both helping international companies to access this highly dynamic market and supporting domestic ones to utilise it as a platform for global growth. Read more. Our services What is your challenge? Americas The vast Americas region is made up of several high-performing markets with huge opportunities — from the USA and Canada in the north, to up-and-coming hotspots like Mexico and Brazil in Latin America.

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DazBob Posted June 14, Posted June 14, Can still taste them, as if I've only just eaten them, every time I burp. Is it just me or does everyone have the same problem? Link to comment Share on other sites More sharing options Replies 57 Created 10 yr Last Reply 10 yr.

Top Posters In This Topic 6 11 10 Popular Days Jun 14 54 Jun 15 4. Popular Days Jun 14 54 posts Jun 15 4 posts.

Popular Posts no balls June 14, Danny G Posted June 14, Little Whitt has the same issue with fanny batter. Smiffs Posted June 14, Bacon Frazzles give me serious acid indigestion. Site Supporter. Winchester White Posted June 14, Has anyone ever wondered whatyour fingers smell like after eating scampi fries? Bag of roasted nuts , packet of mini cheddars both emptied into a big bag of twiglets, extra Worcester sauce shake em Up, eat. Perfect snack pissed up in the pub.

Manky cunt! Chris Heaton-Harris, a member of the European Parliament, said the smoky bacon flavour was a uniquely British and Irish preference. As East Midlands MEP he said he was concerned for food companies who mass produced smoky bacon crisps. Robert Goodwill, MEP for Yorkshire and Humber and also a committee member, criticised the proposals as "over the top". He said the flavouring was a natural one produced by passing smoke through water to create an extract.

By that logic, Mr Goodwill said, traditionally smoked foods which contain the same chemicals in equal or greater quantities should also be banned. Low graphics Accessibility help. News services Your news when you want it. Bacon crisps Cucumber. Littlerobbieh Guest. Jacket potatoes for me. Love them but don't eat them cause they repeat on me for hours and give me the shits. Dave Herbal said:.

Click to expand I had some raw red onion on my salad at lunchtime and I've just had garlic in my tea. It's a good job I'm single really. Sleepy Striker Contributor. Crisps Crisps. Old Prestonian Striker. Cucumber Kippers. Steesafc Striker. Cous cous. Drink lemon water first thing in a morning and it won't happen.

Lambchops Striker. Kebab meat.